Since WordPress 6.3 you can pass an array as the fifth argument of wp_enqueue_script() to set the loading strategy.

function lotgrafix_enqueue_deferred() {
    wp_enqueue_script(
        'lotgrafix-main',
        get_template_directory_uri() . '/js/main.js',
        array(),
        '1.0.0',
        array(
            'strategy'  => 'defer',
            'in_footer' => true,
        )
    );
}
add_action( 'wp_enqueue_scripts', 'lotgrafix_enqueue_deferred' );

Use 'strategy' => 'async' for scripts that do not depend on other scripts or on the DOM order.